Stauffer's Syndrome as Initial Manifestation of Renal Cell Carcinoma: A Case Report.

Abstract

Introduction: Renal cell carcinoma is frequently associated with aretinue of Paraneoplastic syndromes, including Stauffer's syndrome, which is defined as non-metastatic hepatic dysfunction. We present a case of 42yr old, female, who presented with Stauffer's syndrome as initial manifestation of renal cell Carcinoma. Case report: 42-year old, female, being evaluated and managed by the Gastro-enterologist as a case of suspected Primary Liver Carcinoma. She presented with 5month history of Rt. Upper abdominal pain and 1-month history of transient Jaundice which resolved spontaneously. No fever nor features of cholestasis. Examination showed a chronically ill-looking woman, lethargic with poor performance status, and an enlarged, tender liver. Viral Markers were normal while Liver function test showed elevated ALP with normal transaminases. Imaging showed normal liver with a Right renal mass. No evidence of metastasis. Conclusion: Stauffer's syndrome may be the initial manifestation of renal cell carcinoma. A high index of suspicion, and a low threshold for imaging study to exclude renal cell carcinoma should be maintained in patient with unexplained systemic symptoms and hepatic dysfunction.